You can enter the city through the Pan-American Highway, which also has an exit leading towards the mall and the city center. Many buses have stops in Santa Ana, and there is a large bus terminal in the city.Also, taxis can take you there from San Salvador or the Airport.Also, people in El Salvador are simply amazing!
Most buses headed towards San Salvador from Guatemala City stop along 25 Calle Poniente in Santa Ana. Be sure to let the conductor know you want to stop in Santa Ana. Entering from Guatemala may be to your advantage, because tourists from the United States rarely pay the $10 for a tourist card. Four bus lines headed from Guatemala stop through Santa Ana on their way to San Salvador : Tica, Galgos, Melva, and Pezzarossi.
